Protein Name folate receptor beta
Organism Homo sapiens
Gene ID 2350
Gene Symbol

FOLR2

UniProt P14207 (FOLR2_HUMAN)
Relationships Total Number of functionally related compound(s) : 85
Total Number of Articles : 82
Description

folate receptor beta

Gene Summary

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • folate receptor beta
  • folate receptor 2 (fetal)
  • folate receptor alpha
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Properties