Protein Name thrombomodulin
Organism Homo sapiens
Gene ID 7056
Gene Symbol

THBD

UniProt P07204 (TRBM_HUMAN)
Relationships Total Number of functionally related compound(s) : 389
Total Number of Articles : 480
Description

thrombomodulin

Gene Summary

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]

synonyms
  • thrombomodulin
  • CD141 antigen
  • fetomodulin
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Properties