Protein Name cystatin A
Organism Homo sapiens
Gene ID 1475
Gene Symbol

CSTA

UniProt P01040 (CYTA_HUMAN)
Relationships Total Number of functionally related compound(s) : 61
Total Number of Articles : 39
Description

cystatin A

Gene Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

synonyms
  • cystatin-A
  • cystatin A (stefin A)
  • cystatin AS
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Properties