Protein Name X-ray repair complementing defective repair in Chinese hamster cells 4
Organism Mus musculus
Gene ID 108138
Gene Symbol

Xrcc4

UniProt Q924T3 (XRCC4_MOUSE), A0A0R4J024 (A0A0R4J024_MOUSE)
Relationships Total Number of functionally related compound(s) : 11
Total Number of Articles : 9
Description

X-ray repair complementing defective repair in Chinese hamster cells 4

Gene Summary

Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of protection from non-homologous end joining at telomere; and telomeric DNA-containing double minutes formation. Acts upstream of or within several processes, including DNA metabolic process; hemopoiesis; and nervous system development. Located in chromosome, telomeric region. Part of DNA-dependent protein kinase-DNA ligase 4 complex and ERCC4-ERCC1 complex. Is expressed in head; heart; and trunk. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • DNA repair protein XRCC4
  • X-ray repair cross-complementing protein 4
  • 2310057B22Rik
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Properties