Protein Name mitogen-activated protein kinase kinase kinase 11
Organism Homo sapiens
Gene ID 4296
Gene Symbol

MAP3K11

UniProt Q16584 (M3K11_HUMAN), A0A024R5E6 (A0A024R5E6_HUMAN)
Relationships Total Number of functionally related compound(s) : 93
Total Number of Articles : 107
Description

mitogen-activated protein kinase kinase kinase 11

Gene Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

synonyms
  • mitogen-activated protein kinase kinase kinase 11
  • SH3 domain-containing proline-rich kinase
  • mixed lineage kinase 3
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Properties