Protein Name nischarin
Organism Homo sapiens
Gene ID 11188
Gene Symbol

NISCH

UniProt Q9Y2I1 (NISCH_HUMAN)
Relationships Total Number of functionally related compound(s) : 189
Total Number of Articles : 134
Description

nischarin

Gene Summary

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

synonyms
  • nischarin
  • I-1 receptor candidate protein
  • I1R candidate protein
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Properties