Protein Name potassium voltage-gated channel subfamily A member 3
Organism Homo sapiens
Gene ID 3738
Gene Symbol

KCNA3

UniProt P22001 (KCNA3_HUMAN)
Relationships Total Number of functionally related compound(s) : 241
Total Number of Articles : 245
Description

potassium voltage-gated channel subfamily A member 3

Gene Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

synonyms
  • potassium voltage-gated channel subfamily A member 3
  • RP11-284N8.3
  • potassium channel 3
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Properties