| Protein Name | laccase domain containing 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 144811 |
| Gene Symbol | LACC1 |
| UniProt | Q8IV20 (LACC1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
17
Total Number of Articles : 8 |
Description |
laccase domain containing 1 |
| Gene Summary |
This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017] |
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