Protein Name deoxyribonuclease I
Organism Mus musculus
Gene ID 13419
Gene Symbol

Dnase1

UniProt P49183 (DNAS1_MOUSE), Q14BW6 (Q14BW6_MOUSE)
Relationships Total Number of functionally related compound(s) : 126
Total Number of Articles : 124
Description

deoxyribonuclease I

Gene Summary

Enables deoxyribonuclease I activity. Involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in cytoplasmic vesicle and extracellular region. Predicted to be active in nucleus. Is expressed in jejunum; metanephros; and tongue. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • deoxyribonuclease-1
  • DNaseI
  • Dnl1
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Properties