Protein Name hemoglobin subunit alpha 2
Organism Homo sapiens
Gene ID 3040
Gene Symbol

HBA2

UniProt P69905 (HBA_HUMAN), D1MGQ2 (D1MGQ2_HUMAN)
Relationships Total Number of functionally related compound(s) : 159
Total Number of Articles : 241
Description

hemoglobin subunit alpha 2

Gene Summary

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

synonyms
  • hemoglobin subunit alpha
  • alpha globin
  • alpha-2 globin
Click to show/hide the synonyms
Properties