| Protein Name | Ecdysone receptor |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 35540 |
| Gene Symbol | EcR |
| UniProt | P34021 (ECR_DROME), A4UZ51 (A4UZ51_DROME), E1JGY2 (E1JGY2_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
49
Total Number of Articles : 107 |
Description |
Ecdysone receptor |
| Gene Summary |
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein dimerization activity; and transcription coregulator binding activity. Involved in several processes, including heart development; instar larval or pupal development; and nervous system development. Acts upstream of with a positive effect on regulation of macroautophagy. Located in several cellular components, including dendrite; nucleus; and polytene chromosome. Part of activator ecdysone receptor complex and repressor ecdysone receptor complex. Is expressed in several structures, including epithelium; follicle cell; gland; gut section; and larval imaginal tissue. Human ortholog(s) of this gene implicated in cerebral infarction; cerebrovascular disease; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |