Protein Name vacuolar protein sorting 4 homolog A
Organism Homo sapiens
Gene ID 27183
Gene Symbol

VPS4A

UniProt Q9UN37 (VPS4A_HUMAN), A0A024R705 (A0A024R705_HUMAN)
Relationships Total Number of functionally related compound(s) : 31
Total Number of Articles : 43
Description

vacuolar protein sorting 4 homolog A

Gene Summary

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

synonyms
  • vacuolar protein sorting-associated protein 4A
  • SKD1-homolog
  • hVPS4
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Properties