Protein Name ATP-binding cassette, sub-family A member 12
Organism Mus musculus
Gene ID 74591
Gene Symbol

Abca12

UniProt E9Q876 (ABCAC_MOUSE)
Relationships Total Number of functionally related compound(s) : 8
Total Number of Articles : 6
Description

ATP-binding cassette, sub-family A member 12

Gene Summary

Predicted to enable ATPase-coupled transmembrane transporter activity; apolipoprotein A-I receptor binding activity; and lipid transporter activity. Involved in several processes, including corneocyte desquamation; positive regulation of intracellular lipid transport; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within several processes, including positive regulation of cholesterol efflux; positive regulation of protein localization to cell surface; and skin development. Located in cytosol. Is expressed in adrenal gland; epidermis; and gland. Used to study autosomal recessive congenital ichthyosis 4B. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • glucosylceramide transporter ABCA12
  • ATP-binding cassette, sub-family A (ABC1), member 12
  • 4832428G11Rik
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Properties