Protein Name serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Organism Mus musculus
Gene ID 11905
Gene Symbol

Serpinc1

UniProt P32261 (ANT3_MOUSE), Q543J5 (Q543J5_MOUSE)
Relationships Total Number of functionally related compound(s) : 64
Total Number of Articles : 72
Description

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

Gene Summary

Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to nutrient. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in embryo; liver; neural tube; and notochord. Used to study antithrombin III deficiency. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • antithrombin-III
  • anti-thrombin 3
  • antithrombin
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Properties