Protein Name KDEL endoplasmic reticulum protein retention receptor 1
Organism Homo sapiens
Gene ID 10945
Gene Symbol

KDELR1

UniProt P24390 (ERD21_HUMAN)
Relationships Total Number of functionally related compound(s) : 28
Total Number of Articles : 26
Description

KDEL endoplasmic reticulum protein retention receptor 1

Gene Summary

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

synonyms
  • ER lumen protein-retaining receptor 1
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
  • KDEL receptor 1
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Properties