Protein Name acyl-Coenzyme A dehydrogenase, long-chain
Organism Mus musculus
Gene ID 11363
Gene Symbol

Acadl

UniProt P51174 (ACADL_MOUSE), A0A0R4J083 (A0A0R4J083_MOUSE)
Relationships Total Number of functionally related compound(s) : 32
Total Number of Articles : 36
Description

acyl-Coenzyme A dehydrogenase, long-chain

Gene Summary

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

synonyms
  • long-chain specific acyl-CoA dehydrogenase, mitochondrial
  • acetyl-Coenzyme A dehydrogenase, long-chain
  • LCAD
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Properties