| Protein Name | smoothened |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 33196 |
| Gene Symbol | smo |
| UniProt | P91682 (SMO_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
26
Total Number of Articles : 27 |
Description |
smoothened |
| Gene Summary |
Enables phospholipid binding activity; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including eye morphogenesis; imaginal disc morphogenesis; and segment polarity determination. Located in several cellular components, including cilium; dendrite; and neuronal cell body. Colocalizes with axon. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; developmental compartment; epithelium; and head epidermis primordium. Used to study primary bacterial infectious disease. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |