Protein Name ribonuclease L
Organism Homo sapiens
Gene ID 6041
Gene Symbol

RNASEL

UniProt Q05823 (RN5A_HUMAN)
Relationships Total Number of functionally related compound(s) : 154
Total Number of Articles : 169
Description

ribonuclease L

Gene Summary

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]

synonyms
  • 2-5A-dependent ribonuclease
  • 2',5'-oligoisoadenylate synthetase-dependent
  • 2-5A-dependent RNase
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Properties