Protein Name ornithine decarboxylase antizyme 3
Organism Homo sapiens
Gene ID 51686
Gene Symbol

OAZ3

UniProt Q9UMX2 (OAZ3_HUMAN), H0Y7Y4 (H0Y7Y4_HUMAN), A0A0G2JH29 (A0A0G2JH29_HUMAN)
Relationships Total Number of functionally related compound(s) : 16
Total Number of Articles : 12
Description

ornithine decarboxylase antizyme 3

Gene Summary

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]

synonyms
  • ornithine decarboxylase antizyme 3
  • ODC-Az 3
  • antizyme 3
Click to show/hide the synonyms
Properties