| Protein Name | insulin-like growth factor 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16002 |
| Gene Symbol | Igf2 |
| UniProt | P09535 (IGF2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
222
Total Number of Articles : 244 |
Description |
insulin-like growth factor 2 |
| Gene Summary |
This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015] |
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