Protein Name kallikrein related peptidase 7
Organism Homo sapiens
Gene ID 5650
Gene Symbol

KLK7

UniProt P49862 (KLK7_HUMAN), A0A024R4H6 (A0A024R4H6_HUMAN), B4DHX9 (B4DHX9_HUMAN)
Relationships Total Number of functionally related compound(s) : 60
Total Number of Articles : 51
Description

kallikrein related peptidase 7

Gene Summary

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

synonyms
  • kallikrein-7
  • kallikrein 7 (chymotryptic, stratum corneum)
  • serine protease 6
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Properties