Protein Name lactotransferrin
Organism Homo sapiens
Gene ID 4057
Gene Symbol

LTF

UniProt P02788 (TRFL_HUMAN), Q2TUW9 (Q2TUW9_HUMAN), B3KSL2 (B3KSL2_HUMAN), V9HWI4 (V9HWI4_HUMAN), E7ER44 (E7ER44_HUMAN)
Relationships Total Number of functionally related compound(s) : 120
Total Number of Articles : 123
Description

lactotransferrin

Gene Summary

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]

synonyms
  • lactotransferrin
  • epididymis luminal protein 110
  • growth-inhibiting protein 12
Click to show/hide the synonyms
Properties