Protein Name insulin receptor substrate 2
Organism Homo sapiens
Gene ID 8660
Gene Symbol


UniProt Q9Y4H2 (IRS2_HUMAN), Q9P084 (Q9P084_HUMAN)
Relationships Total Number of functionally related compound(s) : 129
Total Number of Articles : 226

insulin receptor substrate 2

Gene Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

  • insulin receptor substrate 2
  • IRS-2
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