| Protein Name | cytochrome P450, family 46, subfamily a, polypeptide 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13116 |
| Gene Symbol | Cyp46a1 |
| UniProt | Q9WVK8 (CP46A_MOUSE), Q3US73 (Q3US73_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
54
Total Number of Articles : 61 |
Description |
cytochrome P450, family 46, subfamily a, polypeptide 1 |
| Gene Summary |
Enables cholesterol 24-hydroxylase activity. Involved in cholesterol catabolic process and regulation of long-term synaptic potentiation. Acts upstream of with a negative effect on protein localization to membrane raft. Located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |