Protein Name dystrobrevin binding protein 1
Organism Mus musculus
Gene ID 94245
Gene Symbol

Dtnbp1

UniProt Q91WZ8 (DTBP1_MOUSE)
Relationships Total Number of functionally related compound(s) : 20
Total Number of Articles : 23
Description

dystrobrevin binding protein 1

Gene Summary

Involved in several processes, including anterograde synaptic vesicle transport; plasma membrane bounded cell projection organization; and regulation of secretion by cell. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of protein serine/threonine kinase activity; and platelet dense granule organization. Located in several cellular components, including growth cone; hippocampal mossy fiber to CA3 synapse; and sarcolemma. Part of BLOC-1 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic vesicle membrane. Is expressed in central nervous system and retina. Used to study Hermansky-Pudlak syndrome 7; platelet storage pool deficiency; and schizophrenia. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • dysbindin
  • BLOC-1 subunit 8
  • HPS7 protein homolog
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Properties