Protein Name uncoupling protein 3
Organism Homo sapiens
Gene ID 7352
Gene Symbol


UniProt P55916 (UCP3_HUMAN), A0A0S2Z4G5 (A0A0S2Z4G5_HUMAN)
Relationships Total Number of functionally related compound(s) : 111
Total Number of Articles : 169

uncoupling protein 3

Gene Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

  • putative mitochondrial transporter UCP3
  • mitochondrial uncoupling protein 3
  • solute carrier family 25 member 9
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