Protein Name DCC netrin 1 receptor
Organism Homo sapiens
Gene ID 1630
Gene Symbol

DCC

UniProt P43146 (DCC_HUMAN), Q49AK4 (Q49AK4_HUMAN)
Relationships Total Number of functionally related compound(s) : 284
Total Number of Articles : 188
Description

DCC netrin 1 receptor

Gene Summary

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

synonyms
  • netrin receptor DCC
  • colorectal cancer suppressor
  • deleted in colorectal carcinoma
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Properties