Protein Name Rho GTPase activating protein 35
Organism Homo sapiens
Gene ID 2909
Gene Symbol

ARHGAP35

UniProt Q9NRY4 (RHG35_HUMAN)
Relationships Total Number of functionally related compound(s) : 39
Total Number of Articles : 59
Description

Rho GTPase activating protein 35

Gene Summary

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

synonyms
  • rho GTPase-activating protein 35
  • glucocorticoid receptor DNA-binding factor 1
  • glucocorticoid receptor repression factor 1
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Properties