CPRiL

Protein Name	Rap guanine nucleotide exchange factor 4
Organism	Homo sapiens
Gene ID	11069
Gene Symbol	RAPGEF4
UniProt	Q8WZA2 (RPGF4_HUMAN), B7Z278 (B7Z278_HUMAN)
Relationships	Total Number of functionally related compound(s) : 72 Total Number of Articles : 112
Description	Rap guanine nucleotide exchange factor 4
Gene Summary	Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Ras protein signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to act upstream of or within with a positive effect on hormone secretion. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in membrane. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density; and presynapse. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Jul 2025]
synonyms	rap guanine nucleotide exchange factor 4 RAP guanine-nucleotide-exchange factor (GEF) 4 Rap guanine nucleotide exchange factor (GEF) 4 cAMP-regulated guanine nucleotide exchange factor II exchange factor directly activated by cAMP 2 exchange protein directly activated by cAMP 2 putative protein product of Nbla00496 CAMP-GEFII CGEF2 EPAC EPAC 2 EPAC2 Nbla00496 Click to show/hide the synonyms
Properties