Protein Name insulin induced gene 2
Organism Homo sapiens
Gene ID 51141
Gene Symbol

INSIG2

UniProt Q9Y5U4 (INSI2_HUMAN), A0A024RAI2 (A0A024RAI2_HUMAN), B4DQ23 (B4DQ23_HUMAN)
Relationships Total Number of functionally related compound(s) : 36
Total Number of Articles : 54
Description

insulin induced gene 2

Gene Summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

synonyms
  • insulin-induced gene 2 protein
  • INSIG2 membrane protein
  • insulin induced protein 2
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Properties