Protein Name ATPase H+ transporting V0 subunit a2
Organism Homo sapiens
Gene ID 23545
Gene Symbol


UniProt Q9Y487 (VPP2_HUMAN)
Relationships Total Number of functionally related compound(s) : 320
Total Number of Articles : 335

ATPase H+ transporting V0 subunit a2

Gene Summary

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

  • V-type proton ATPase 116 kDa subunit a 2
  • A2V-ATPase
  • ATPase, H+ transporting, lysosomal V0 subunit a2
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