Protein Name Rho guanine nucleotide exchange factor 7
Organism Homo sapiens
Gene ID 8874
Gene Symbol

ARHGEF7

UniProt Q14155 (ARHG7_HUMAN), A0A024RDY9 (A0A024RDY9_HUMAN), B7Z344 (B7Z344_HUMAN), Q5W9H1 (Q5W9H1_HUMAN), B7Z6G2 (B7Z6G2_HUMAN), E9PDQ5 (E9PDQ5_HUMAN)
Relationships Total Number of functionally related compound(s) : 36
Total Number of Articles : 46
Description

Rho guanine nucleotide exchange factor 7

Gene Summary

This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]

synonyms
  • rho guanine nucleotide exchange factor 7
  • PAK-interacting exchange factor beta
  • Rho guanine nucleotide exchange factor (GEF) 7
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Properties