Protein Name vav guanine nucleotide exchange factor 3
Organism Homo sapiens
Gene ID 10451
Gene Symbol

VAV3

UniProt Q9UKW4 (VAV3_HUMAN)
Relationships Total Number of functionally related compound(s) : 32
Total Number of Articles : 37
Description

vav guanine nucleotide exchange factor 3

Gene Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • guanine nucleotide exchange factor VAV3
  • VAV-3
  • vav 3 guanine nucleotide exchange factor
Click to show/hide the synonyms
Properties