Protein Name ATP binding cassette subfamily B member 11
Organism Rattus norvegicus
Gene ID 83569
Gene Symbol

Abcb11

UniProt O70127 (ABCBB_RAT), A0A2P1EA62 (A0A2P1EA62_RAT)
Relationships Total Number of functionally related compound(s) : 128
Total Number of Articles : 141
Description

ATP binding cassette subfamily B member 11

Gene Summary

Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; response to 17alpha-ethynylestradiol; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • bile salt export pump
  • ATP-binding cassette sub-family B member 11
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11
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Properties