Protein Name dentin matrix acidic phosphoprotein 1
Organism Homo sapiens
Gene ID 1758
Gene Symbol

DMP1

UniProt Q13316 (DMP1_HUMAN)
Relationships Total Number of functionally related compound(s) : 114
Total Number of Articles : 116
Description

dentin matrix acidic phosphoprotein 1

Gene Summary

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • dentin matrix acidic phosphoprotein 1
  • dentin matrix protein 1
  • ARHP
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Properties