Protein Name nerve growth factor
Organism Mus musculus
Gene ID 18049
Gene Symbol

Ngf

UniProt P01139 (NGF_MOUSE), Q6LDU8 (Q6LDU8_MOUSE)
Relationships Total Number of functionally related compound(s) : 420
Total Number of Articles : 439
Description

nerve growth factor

Gene Summary

Enables transmembrane receptor protein tyrosine kinase activator activity. Involved in positive regulation of DNA binding activity; positive regulation of Ras protein signal transduction; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell projection organization; and positive regulation of macromolecule metabolic process. Located in neuron projection terminus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • beta-nerve growth factor
  • nerve growth factor, beta
  • Ngfb
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Properties