Protein Name prostaglandin E receptor 4 (subtype EP4)
Organism Mus musculus
Gene ID 19219
Gene Symbol


UniProt P32240 (PE2R4_MOUSE), Q91VE4 (Q91VE4_MOUSE)
Relationships Total Number of functionally related compound(s) : 159
Total Number of Articles : 340

prostaglandin E receptor 4 (subtype EP4)

Gene Summary

Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; regulation of cytokine production; and regulation of stress fiber assembly. Acts upstream of or within several processes, including cellular response to mechanical stimulus; regulation of ossification; and response to lipopolysaccharide. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; early conceptus; heart valve; retina; and secondary oocyte. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

  • prostaglandin E2 receptor EP4 subtype
  • PGE2 receptor EP4 subtype
  • prostanoid EP4 receptor
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