Protein Name doublesex and mab-3 related transcription factor 1
Organism Homo sapiens
Gene ID 1761
Gene Symbol

DMRT1

UniProt Q9Y5R6 (DMRT1_HUMAN)
Relationships Total Number of functionally related compound(s) : 63
Total Number of Articles : 91
Description

doublesex and mab-3 related transcription factor 1

Gene Summary

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

synonyms
  • doublesex- and mab-3-related transcription factor 1
  • DM domain expressed in testis 1
  • DM domain expressed in testis protein 1
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Properties