Protein Name bone morphogenetic protein receptor type 2
Organism Mus musculus
Gene ID 12168
Gene Symbol

Bmpr2

UniProt O35607 (BMPR2_MOUSE), Q3UU71 (Q3UU71_MOUSE), Q3UG09 (Q3UG09_MOUSE), Q3UER5 (Q3UER5_MOUSE)
Relationships Total Number of functionally related compound(s) : 58
Total Number of Articles : 50
Description

bone morphogenetic protein receptor type 2

Gene Summary

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

synonyms
  • bone morphogenetic protein receptor type-2
  • BMP type II receptor
  • BMP type-2 receptor
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Properties