Protein Name early growth response 1
Organism Mus musculus
Gene ID 13653
Gene Symbol

Egr1

UniProt P08046 (EGR1_MOUSE), Q544D6 (Q544D6_MOUSE), Q8CAT6 (Q8CAT6_MOUSE)
Relationships Total Number of functionally related compound(s) : 305
Total Number of Articles : 366
Description

early growth response 1

Gene Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to gamma radiation; regulation of gene expression; and regulation of hormone biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • early growth response protein 1
  • Krox-24 nuclear protein
  • nerve growth factor-induced protein A
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Properties