Protein Name C-type lectin domain family 4 member G
Organism Homo sapiens
Gene ID 339390
Gene Symbol


Relationships Total Number of functionally related compound(s) : 15
Total Number of Articles : 15

C-type lectin domain family 4 member G

Gene Summary

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

  • C-type lectin domain family 4 member G
  • C-type lectin superfamily 4, member G
  • liver and lymph node sinusoidal endothelial cell C-type lectin
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