| Protein Name | C-type lectin domain family 4 member G |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 339390 |
| Gene Symbol | CLEC4G |
| UniProt | Q6UXB4 (CLC4G_HUMAN), Q08G24 (Q08G24_HUMAN), Q6XYD1 (Q6XYD1_HUMAN), B7ZKQ2 (B7ZKQ2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
15
Total Number of Articles : 15 |
Description |
C-type lectin domain family 4 member G |
| Gene Summary |
This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] |
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