| Protein Name | inositol 1,4,5-trisphosphate receptor type 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3709 |
| Gene Symbol | ITPR2 |
| UniProt | Q14571 (ITPR2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
27
Total Number of Articles : 42 |
Description |
inositol 1,4,5-trisphosphate receptor type 2 |
| Gene Summary |
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015] |
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