Protein Name unc-51 like kinase 1
Organism Mus musculus
Gene ID 22241
Gene Symbol

Ulk1

UniProt O70405 (ULK1_MOUSE), Q6PB82 (Q6PB82_MOUSE), A0A0R4J0B3 (A0A0R4J0B3_MOUSE)
Relationships Total Number of functionally related compound(s) : 118
Total Number of Articles : 114
Description

unc-51 like kinase 1

Gene Summary

Enables Hsp90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including nervous system development; protein autophosphorylation; and regulation of neurotrophin TRK receptor signaling pathway. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • serine/threonine-protein kinase ULK1
  • serine/threonine-protein kinase Unc51.1
  • Unc51.1
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Properties