Protein Name rolled
Organism Drosophila melanogaster
Gene ID 3354888
Gene Symbol

rl

UniProt P40417 (ERKA_DROME), A8Y4W5 (A8Y4W5_DROME)
Relationships Total Number of functionally related compound(s) : 63
Total Number of Articles : 65
Description

rolled

Gene Summary

Enables MAP kinase activity and protein kinase binding activity. Involved in several processes, including open tracheal system development; post-embryonic animal organ development; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in cytosol; neuromuscular junction; and nucleus. Is expressed in several structures, including extended germ band embryo; imaginal disc; midgut; presumptive embryonic/larval central nervous system; and wing. Used to study cancer. Human ortholog(s) of this gene implicated in Noonan syndrome 13; carcinoma (multiple); and pulmonary hypertension. Orthologous to several human genes including MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • rolled
  • CG12559-PA
  • CG12559-PC
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Properties