| Protein Name | ras homolog family member H |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 399 |
| Gene Symbol | RHOH |
| UniProt | Q15669 (RHOH_HUMAN), Q6ICP4 (Q6ICP4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
504
Total Number of Articles : 342 |
Description |
ras homolog family member H |
| Gene Summary |
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013] |
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