Protein Name ras homolog family member H
Organism Homo sapiens
Gene ID 399
Gene Symbol

RHOH

UniProt Q15669 (RHOH_HUMAN), Q6ICP4 (Q6ICP4_HUMAN)
Relationships Total Number of functionally related compound(s) : 504
Total Number of Articles : 342
Description

ras homolog family member H

Gene Summary

The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

synonyms
  • rho-related GTP-binding protein RhoH
  • GTP-binding protein TTF
  • TTF, translocation three four
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Properties