Protein Name sphingosine kinase 2
Organism Mus musculus
Gene ID 56632
Gene Symbol

Sphk2

UniProt Q9JIA7 (SPHK2_MOUSE), Q58E38 (Q58E38_MOUSE), Q3U912 (Q3U912_MOUSE)
Relationships Total Number of functionally related compound(s) : 66
Total Number of Articles : 88
Description

sphingosine kinase 2

Gene Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

synonyms
  • sphingosine kinase 2
  • Sk2
  • Spk2
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Properties