Protein Name aldo-keto reductase family 1 member C3
Organism Homo sapiens
Gene ID 8644
Gene Symbol


UniProt P42330 (AK1C3_HUMAN), A0A0A0MSS8 (A0A0A0MSS8_HUMAN), B4DKT3 (B4DKT3_HUMAN)
Relationships Total Number of functionally related compound(s) : 408
Total Number of Articles : 373

aldo-keto reductase family 1 member C3

Gene Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

  • aldo-keto reductase family 1 member C3
  • 3-alpha hydroxysteroid dehydrogenase, type II
  • 3-alpha-HSD type II, brain
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