Protein Name C-X-C motif chemokine receptor 1
Organism Homo sapiens
Gene ID 3577
Gene Symbol

CXCR1

UniProt P25024 (CXCR1_HUMAN)
Relationships Total Number of functionally related compound(s) : 129
Total Number of Articles : 151
Description

C-X-C motif chemokine receptor 1

Gene Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

synonyms
  • C-X-C chemokine receptor type 1
  • CXC-R1
  • CXCR-1
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Properties