Protein Name sigma non-opioid intracellular receptor 1
Organism Homo sapiens
Gene ID 10280
Gene Symbol

SIGMAR1

UniProt Q99720 (SGMR1_HUMAN), A2A3U5 (A2A3U5_HUMAN), B4DR71 (B4DR71_HUMAN)
Relationships Total Number of functionally related compound(s) : 133
Total Number of Articles : 127
Description

sigma non-opioid intracellular receptor 1

Gene Summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

synonyms
  • sigma non-opioid intracellular receptor 1
  • SR31747 binding protein 1
  • aging-associated gene 8 protein
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Properties