Protein Name F-box protein 32
Organism Homo sapiens
Gene ID 114907
Gene Symbol

FBXO32

UniProt Q969P5 (FBX32_HUMAN), A0A024R9F3 (A0A024R9F3_HUMAN), Q0VAQ6 (Q0VAQ6_HUMAN), Q498Y9 (Q498Y9_HUMAN), I6L984 (I6L984_HUMAN)
Relationships Total Number of functionally related compound(s) : 90
Total Number of Articles : 105
Description

F-box protein 32

Gene Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

synonyms
  • F-box only protein 32
  • atrogin 1
  • muscle atrophy F-box protein
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Properties